Diastolic function in hypertrophic cardiomyopathy: effects of propranolol and verapamil on diastolic stiffness
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چکیده
منابع مشابه
Effects of verapamil on left ventricular systolic function and diastolic filling in patients with hypertrophic cardiomyopathy.
Verapamil improves exercise capacity in patients with hypertrophic cardiomyopathy (HCM), but its mechanism of action are unknown. We examined the effects of oral verapamil (320-480 mg/day) on resting left ventricular (LV) systolic and diastolic function in patients with HCM. High-temporal-resolution time-activity curves from gated technetium-99m radionuclide angiograms were analyzed before and ...
متن کاملHypertrophic cardiomyopathy and diastolic dysfunction.
Hypertrophic cardiomyopathy (HCM) is a disease state with characteristic pathologic changes most likely to result in abnormalities of diastolic function. Indeed, HCM may well be considered a “poster child” for diastolic dysfunction, because pronounced ventricular hypertrophy is associated with a reduced left ventricular (LV) cavity. The pressurevolume relationship would almost certainly be shif...
متن کاملHypertrophic obstructive cardiomyopathy. Effects of acute and chronic verapamil treatment on left ventricular systolic and diastolic function.
Changes in left ventricular systolic and diastolic function and outflow gradient were evaluated in patients with obstructive hypertrophic cardiomyopathy after intravenous acute treatment with verapamil (15 patients) and after six months of oral chronic treatment (11 patients). All patients had severe symptoms despite beta blockade, and the condition of all but two improved appreciably after chr...
متن کاملLeft ventricular diastolic gradient in hypertrophic cardiomyopathy☆
Systolic left ventricular (LV) gradients and diastolic dysfunction are widely studied in hypertrophic cardiomyopathy (HCM) [1,2], however diastolic gradients have never been described. A patient with HCM, mid-cavity obliteration and apical aneurysm, diagnosed by both 2D echocardiography (Fig. 1, panel A) and cardiac magnetic resonance (Fig. 1, panel B), showed color Doppler aliasing effect at m...
متن کاملLeft ventricular end-diastolic pressure-volume relationships in hypertrophic cardiomyopathy. Changes induced by verapamil.
In 16 patients with hypertrophic cardiomyopathy, an acute response of the left ventricular end-diastolic pressure and volume index to intravenously administered verapamil was assessed. Verapamil decreased the left ventricular end-diastolic pressure from 20 +/- 6 to 17 +/- 5 mm Hg(p less than 0.001) and increased the end-diastolic volume index from 82 +/- 22 to 91 +/- 23 ml/sqm (p less than 0.01...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 1983
ISSN: 0195-668X,1522-9645
DOI: 10.1093/eurheartj/4.suppl_f.47